The majority of patients with gonadotrophinomas are middle-aged men. These patients develop impotence and also suffer from visual disturbances. A diagnosis of primary hypogonadism is usually ruled out at an early stage. Some of the patients will have panhypopituitarism but with no loss of libido.
The symptoms of TSHomas are very non-specific with the patients usually being male and presenting with headaches and visual disturbances. Some of the patients are thyrotoxic and are discovered due to their high levels of TSH compared to the expected low levels. Other TSHomas are associated with hypothyroidism.